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Title page for ETD etd-12172012-152921

Type of Document Master's Thesis
Author Smith, Byron Fitzgerald
Author's Email Address byron.smith@vanderbilt.edu
URN etd-12172012-152921
Title Wireless Insufflation for Wireless Capsule Endoscopy
Degree Master of Science
Department Mechanical Engineering
Advisory Committee
Advisor Name Title
Robert Webster III Committee Chair
Pietro Valdastri Committee Member
Thomas Withrow Committee Member
  • Capsule Robotics
  • Wireless Capsule Endoscopy
  • Wireless Capsule Colonoscopy
  • Colorectal Cancer Screening
Date of Defense 2012-12-11
Availability unrestricted
Robotic mechanisms promise to enhance the diagnostic abilities of capsule endoscopes, endow them with novel interventional capabilities and reduce the invasiveness of endoscopy. The success of traditional endoscopy in diagnosing disease of the gastrointestinal (GI) tract can be attributed to the clear view that such techniques provide of the intestinal lumen and the range of motion they are capable of displaying. When viewed in the context of capsule endoscopy, the ability to clearly view tissue and navigate within the GI track both depend on the ability to distend tissue. In an effort to bring this functionality to wireless capsule endoscopy, the present investigation examines the feasibility of generating a significant volume of gas from a capsule based-platform. Success of the system is determined by its ability to provide a level of insufflation that is necessary to enhance visualization, and allow for magnetic locomotion, within the colon. As such, this research begins by quantifying the amount of gas that must be introduced to the colon to enhance visualization and magnetic locomotion. Once the desired level of insufflation is established, various chemical reactions are evaluated for use as a gas generator within capsule-based devices. Finally, prototypes are designed, fabricated and tested to demonstrate the feasibility of wireless capsule insufflation.

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