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Title page for ETD etd-12012008-163706

Type of Document Dissertation
Author Lowe, John Stewart
Author's Email Address john.lowe@vanderbilt.edu
URN etd-12012008-163706
Title Targeting of the cardiac voltage-gated sodium channel 1.5 requires an ankyrin-G-dependent pathway
Degree PhD
Department Pathology
Advisory Committee
Advisor Name Title
Richard Hoover Committee Chair
  • ankyrin-G
  • Nav1.5
  • Sodium channels -- Pathophysiology
  • Heart -- Pathophysiology
  • Arrhythmia -- Pathophysiology
Date of Defense 2008-11-04
Availability unrestricted
The focus of this project is determining if an ankyrin-G-dependent pathway controls the membrnae expression of the voltage-gated sodium channel 1.5 in cardiomyocytes. Disruption of the normal localization of Nav1.5 can result in Brugada syndrome and has been linked to myopathic disease.

This project defines that an ankyrin-G-based pathway is required for the expression, localization and function of Nav1.5 at the cariomyocyte plasma membrane.

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