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Title page for ETD etd-11302006-141540

Type of Document Master's Thesis
Author Sexton, John Andrew
Author's Email Address john@improvnashville.com
URN etd-11302006-141540
Title SENSE & Susceptibility: Respiration-Related Susceptibility Effects and their Interactions with Parallel Imaging
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
John Gore Committee Chair
Chris Gatenby Committee Co-Chair
  • MRI
  • magnetic susceptibility
  • parallel imaging
  • center of mass
  • respiratory effects
  • physiological noise
  • respiration
Date of Defense 2006-11-15
Availability unrestricted
Most functional MRI studies rely on fast Echo Planar Imaging, which is sensitive to magnetic susceptibility effects. These effects can lead to image-to-image signal instability, reducing the reliability of functional activation maps. Respiration is responsible for a significant component of image-to-image variance, but no widely effective method for correcting respiration-based susceptibility effects is available.

We demonstrate a relationship between respiration-related susceptibility effects in the presence of parallel imaging acquisitions and apply our findings to analyze the behavior of IMPACT (IMage-based Physiological Artifact Correction Technique). Based on our findings regarding IMPACT, we propose COMPACT (Center of Mass-based Physiological Artifact Correction Technique), a new method which provides a reliable estimate of respiratory effects based on the motion of an image set’s center of mass (centroid) through time.

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