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Title page for ETD etd-11222010-150037

Type of Document Master's Thesis
Author Balinski, Andrzej
Author's Email Address andrzej.balinski@vanderbilt.edu
URN etd-11222010-150037
Title Improved synthesis of tetraethylene glycol-derived thiol for monolayer-protected gold nanoparticles
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
David Cliffel Committee Member
David Wright Committee Member
  • mercaptotetraethylene glycol
  • gold nanoparticles
Date of Defense 2010-11-22
Availability unrestricted
Improved synthesis of ω-functionalized mercapto-tetraethylene glycols and single-phase synthesis of gold nanoparticles are described. Tetraethylene glycol is converted to mercaptotetraethylene glycol through thioacetate-protected tetraethylene glycol. The formation of disulfide byproducts are easily prevented by isolating the protected mercaptan which can be stored and quickly de-protected when needed. More importantly, mercaptotetraethylene glycol allows the simple one-step preparation of protected, water-soluble gold nanoparticles within a single alcoholic phase. This method avoids the problem of persistent ionic contamination from residual phase-transfer agent. These types of nanoparticles could provide a good starting material for biological applications due to their enhanced hydrophilicity and strong stability.
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