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Title page for ETD etd-11212016-145818

Type of Document Master's Thesis
Author Dockery, Mary Diana
URN etd-11212016-145818
Title Focused Ultrasound for the Generation of Cancer Immunotherapy
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Todd D Giorgio Committee Chair
Charles F Caskey Committee Member
  • immunotherapy
  • focused ultrasound
  • breast cancer
Date of Defense 2016-11-18
Availability unrestricted
Cancer immunotherapies, which seek to arm the patient’s own immune system for personalized therapy, are a promising option for effective elimination of tumors. Focused ultrasound (FUS) is one propitious method for generating anti-tumor immunotherapy, advantageous in its capacity to deliver non-ionizing, non-invasive, tumor-localized treatment; this involves the transdermal deposition of sonic energy at a focal point in the tumor, which induces acute inflammation capable of activating an anti-tumor immune response. Here, we characterize, in vivo, the early (48 hours) adaptive anti-tumor immune responses induced by FUS treatment of tumors. Compared to untreated tumors, tumors treated with mechanical FUS (mFUS) demonstrated increased NF-κB activation in local and distant tumors. Additionally, a “responder” subset of mFUS-treated mice was identified and mFUS-treated tumors exhibited an increased percent of CD4+ T cells and an increased CD4+/CD8+ T cell ratio, as compared to untreated tumors. Immunohistochemical analysis of CD4+ T cells revealed a higher presence of immunostimulatory phenotypes in mFUS-treated tumors compared to untreated tumors. Taken together, these results suggested a FUS-induced shift towards anti-tumor immune activity.
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