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Title page for ETD etd-10282016-153112

Type of Document Dissertation
Author Lankford, Christopher Lynn
Author's Email Address christopher.l.lankford@vanderbilt.edu
URN etd-10282016-153112
Title Multiple Echo, Caesar Cipher Acquisition and Model-Based Reconstruction (ME-CAMBREC): a Novel Accelerated T2 Mapping Method
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Mark D. Does Committee Chair
Bruce M. Damon Committee Member
Daniel F. Gochberg Committee Member
E. Brian Welch Committee Member
William A. Grissom Committee Member
  • MRI
  • T2
  • fast imaging
  • model-based reconstruction
  • parametric constraint
Date of Defense 2016-10-12
Availability unrestricted
Due to the need to acquire a series of T2-weighted images, quantitative T2 mapping protocols in magnetic resonance imaging (MRI) suffer from long scan times. In order to alleviate this problem, fast spin-echo (FSE) imaging protocols can be employed, but the resulting images contain errors in the form of smoothing and ghosting artifacts which propagate to T2 maps. This dissertation presents a new method, dubbed Multiple Echo, Caesar Cipher Acquisition and Model-Based Reconstruction (ME-CAMBREC), which explicitly accounts for k-space signal attenuation during the reconstruction step. T2 maps generated by ME-CAMBREC contained reduced artifact compared to those generated by FSE methods, while requiring only a fraction of the scan time of a multiple spin-echo protocol. For moderate-to-high acceleration factors, ME-CAMBREC outperformed parallel imaging and steady-state T2 mapping techniques. Data suitable for ME-CAMBREC can be acquired in multi-slice mode using pulse sequence interleafs, but a slice gap should be employed to limit T2 bias caused by radiofrequency profile effects. Although ME-CAMBREC can be used to generate accurate T2s in the presence of flip angle errors, it was shown that the use of an independent measure of the transmit field (B1+) will improve fitted T2 precision.
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