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Title page for ETD etd-10262014-201331

Type of Document Dissertation
Author Malinowski, Jennifer Renee
Author's Email Address jennifer.malinowski@vanderbilt.edu
URN etd-10262014-201331
Title Women's Health: Genetic Variation in Complex Traits
Degree PhD
Department Human Genetics
Advisory Committee
Advisor Name Title
Melinda Aldrich, Ph.D., M.P.H. Committee Chair
Dana C. Crawford, Ph.D. Committee Co-Chair
Digna Velez-Edwards, Ph.D. Committee Member
Ellen Wright Clayton, MD, JD Committee Member
William S. Bush, Ph.D., M.S. Committee Member
  • personalized medicine
  • women's health
  • human genetics
Date of Defense 2014-08-20
Availability unrestricted
Personalized medicine, the individualization of clinical care based, in part, upon an individual’s genetic background, can be thought of as a three step process: scientific discovery, validation, and clinical implementation. Women and individuals of diverse ethnic/racial backgrounds are at risk of widening health disparities unless additional emphasis is placed upon these subjects for future research. Genetic association studies were used to identify genetic variants that contribute to the timing of the reproductive lifespan in women, endometrial cancer, and elevated serum thyroid stimulating hormone levels. A rapid evidence review was performed to validate previously reported variants associated with hypothyroidism and consider the analytic evidence that genetic testing of asymptomatic adult women leads to improved health outcomes. The ethical, legal, and social impacts of personalized medicine implementation were evaluated from the perspectives of both the health care system and the general public.
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Malinowskifinal.pdf 2.21 Mb 00:10:12 00:05:15 00:04:35 00:02:17 00:00:11

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