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Title page for ETD etd-10052005-113141

Type of Document Dissertation
Author Osler, Megan Emery
Author's Email Address meganosler@yahoo.com
URN etd-10052005-113141
Title Characterization of Bves Function in Epithelial Integrity
Degree PhD
Department Cell and Developmental Biology
Advisory Committee
Advisor Name Title
Kathleen Gould Committee Chair
David Bader Committee Member
Gary Olson Committee Member
Robert Coffey Committee Member
Robert Matusik Committee Member
  • cell adhesion
  • development
  • epithelia
  • tight junction
  • Bves
  • Cell adhesion molecules
  • Epithelial cells -- Physiology
Date of Defense 2005-07-28
Availability unrestricted
The work contained in this document provides the first description and characterization of Bves, a gene product identified by our laboratory, in epithelial cell types. Studies addressed a central hypothesis that Bves plays a role in epithelial cell-cell interaction and integrity, which is supported by an initial protein distribution analysis at cell membranes in both cells and tissues. Localization, interaction, and functional assays establish that Bves is an essential component of the tight junction complex and interacts with the protein complex containing ZO-1 in epithelial cells. Furthermore, in vivo experiments demonstrate that Bves is clearly important for epithelial morphogenesis during X. laevis development, and establish an excellent model system to perform future studies. This dissertation provides an important contribution to the body of literature on the Bves by defining the essential nature of Bves in epithelial integrity and by providing the groundwork for further examination of how Bves participates in epithelial cell interaction.
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