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Title page for ETD etd-09252018-165508


Type of Document Master's Thesis
Author Benning, Ronald Tony Alan, Jr.
Author's Email Address ronald.t.benning@vanderbilt.edu
URN etd-09252018-165508
Title Towards the Development of Alanine Serine Cysteine Transporter 2-Selective Inhibitors and Molecular Probes to Interrogate Cancer Metabolism
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Henry Charles Manning Committee Chair
Jeffrey N. Johnston Committee Member
Steven D. Townsend Committee Member
Keywords
  • ASCT-2 inhibition
  • glutamine metabolism
  • glutamine
  • Molecular probes
  • glutamine uptake
Date of Defense 2018-05-15
Availability restrictone
Abstract
ASCT-2 is an evolutionary redundant neutral amino acid transporter protein that has been consistently reported as being expressed at elevated levels in high profile malignant diseases, such as breast, lung, and gastrointestinal cancers. Its role in cancer metabolism has been elucidated as a primary and selective transporter of L-glutamine, an endogenous substrate utilized as a nitrogenous source of fuel used to sustain high cellular proliferation rates. ASCT-2 over-expression has been linked with high-mortality diseases, including breast and colorectal cancers, attributed to advanced tumor development. The important role of ASCT-2 as a major contributor to glutamine intake, in cancer metabolism, presents a unique opportunity for medicinal development of novel therapeutics in selectively targeting ASCT-2 inhibition and remediate tumor growth. This work entails a medicinal campaign towards the discovery and development of novel pharmaceuticals for the inhibition of ASCT-2 mediated glutamine uptake.
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