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Title page for ETD etd-09142009-161041

Type of Document Dissertation
Author Anderson, Michael Andrew
URN etd-09142009-161041
Title Regulation of dynein-dynactin during Drosophila spermatogenesis
Degree PhD
Department Cell and Developmental Biology
Advisory Committee
Advisor Name Title
David Miller Committee Chair
Daniela Drummond-Barbosa Committee Member
Ethan Lee Committee Member
Karen Hales Committee Member
Laura Lee Committee Member
  • meiosis
  • dynein
  • dynactin
  • centrosome
  • nucleus
  • spermatogenesis
  • Drosophila
  • cell cycle
Date of Defense 2009-05-12
Availability unrestricted

Dynein is a minus-end directed microtubule motor complex that is required for a diverse range of biological processes, from intracellular-cargo transport to cell migration. Dynein is regulated at multiple levels and its functions are dictated by its affinity for microtubules, motor action, associations with specific cargos, and subcellular localization.

During Drosophila spermatogenesis, dynein localizes to the nuclear surface at entry into meiotic prophase where it plays an essential role in mediating nucleus-centrosome coupling. Dynein also localizes to the nuclear surface of early postmeiotic spermatids, where it maintains associations between the nucleus and basal body and controls the position of the nucleus during elongation. I have identified the conserved gene asunder (asun) as a novel regulator of dynein’s localization to the nuclear surface during Drosophila spermatogenesis. In addition, I have found that the dynein regulatory factor, Lis-1, also plays an essential role in promoting the localization of dynein to the nuclear surface, and that it may cooperate with asun in this process.

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