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Title page for ETD etd-06092014-132843

Type of Document Dissertation
Author Coffey, Aaron Michael
Author's Email Address aaron.coffey@vanderbilt.edu
URN etd-06092014-132843
Title Sensitive Molecular Magnetic Resonance Imaging Of Hyperpolarized Contrast Agents In Low Magnetic Fields
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Eduard Y. Chekmenev Committee Chair
John C. Gore Committee Member
Kevin W. Waddell Committee Member
Wellington Pham Committee Member
William A. Grissom Committee Member
  • parahydrogen
  • xenon-129
  • low-field MRI
  • hyperpolarization
  • hyperpolarizer
  • contrast agent
Date of Defense 2014-05-29
Availability unrestricted
Nuclear spin polarization P is a key factor in overall Magnetic Resonance (MR) sensitivity, and conventionally is of order 10-6 owing to the tyranny of its induction by the strength of the detection magnetic field. But various hyperpolarization mechanisms applied externally to the detection field can temporarily increase nuclear spin polarization to near unity (P = 1). The resulting increased MR signal enables a variety of applications, including biomedical use of hyperpolarized (HP) contrast agents to assay cellular metabolism via Magnetic Resonance Imaging (MRI), typically 13C-labeled metabolites reporting on abnormal metabolism. In this work optimization of radiofrequency (RF) coils and hyperpolarizer automation are used to increase the detection sensitivity of hyperpolarized contrast agents (HCA) and improve their production. It is shown that low-field imaging can be more sensitive than corresponding high-field detection when using RF coils optimized to the resonant frequency. The feasibility of low-field molecular imaging of 1H and 13C HCA with high spatial resolution (as fine as 94×94 μm2) is demonstrated with low-field 38 mm inner diameter RF coils at a static magnetic field strength B0 = 0.0475 T, achieving signal-to-noise ratios suitable for in vivo imaging studies.
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