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Title page for ETD etd-04172008-172151

Type of Document Dissertation
Author Dula, Adrienne Nicole
Author's Email Address adrienne.n.dula@vanderbilt.edu
URN etd-04172008-172151
Title Micro-anatomical characterization of central white matter using magnetic resonance imaging
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Dr. Mark Does Committee Chair
Adam Anderson Committee Member
Bill Valentine Committee Member
Dan Gochberg Committee Member
John Gore Committee Member
  • quantitative magnetization transfer
  • multiexponential T2
  • Spinal cord -- Magnetic resonance imaging
  • myelin
  • Myelination
Date of Defense 2008-04-14
Availability unrestricted
Most magnetic resonance imaging techniques offer tissue contrast but provide limited information regarding the variation of the magnetic resonance signal that exists on a smaller scale. The magnetic resonance signal arising from a heterogeneous tissue, such as spinal cord white matter, is the sum of signals from each tissue compartment within the imaging voxel. Analysis of this signal can better characterize the micro-anatomical heterogeneity tissue, white matter in particular. Many questions remain with regard to the compartmental contributions for the various types of magnetic resonance imaging (MRI) contrast. This project utilizes a variety of in vitro studies as well as simulations to better characterize the contribution of different water compartments to conventional MRI methods. Such an understanding of the complex combination of the various relaxation and exchange properties is important in developing an anatomical basis for interpreting magnetization transfer and T2 weighted images, particularly with respect to myelination.
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