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Title page for ETD etd-04082016-122421

Type of Document Master's Thesis
Author Wang, Bingshu
URN etd-04082016-122421
Title Measurement of Albumin Concentration Gradients within the Glomerular Capillary Wall Based on Active Contour Model
Degree Master of Science
Department Electrical Engineering
Advisory Committee
Advisor Name Title
D. Mitchell Wilkes, Ph.D. Committee Chair
H. William Fissell IV, M.D Committee Member
  • glomerular basement membrane
  • active contour
  • glomerular capillary wall
Date of Defense 2016-05-13
Availability unrestricted
The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus. The passage of various endogenous proteins across the GBM has been measured and studied by others. This paper studied a method, based on an active contour model, to measure the protein concentration gradients across the GBM. Glomerular capillary images of living rats were obtained by confocal microscopy. After preprocessing, the active contour model was applied on the scanned images to estimate the location of the GBM. A sampling across the GBM in selected areas was then applied and the result was averaged for future analysis.
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