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Title page for ETD etd-04052006-135219

Type of Document Dissertation
Author Miller, Scott Alan
Author's Email Address scott.a.miller.1@vanderbilt.edu
URN etd-04052006-135219
Title Peptides and proteins: anti-virals to novel materials
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
David W. Wright Committee Chair
Brian Bachmann Committee Member
Carmello Rizzo Committee Member
Eva Harth Committee Member
James Crowe Jr. Committee Member
  • Ionic solutions
  • Membrane proteins -- Structure -- Computer simulation
  • Bioactive compounds -- Synthesis
  • Peptides -- Synthesis
  • Biologically Active Materials
  • Novel Silica Materials
  • Solvents
  • Antiviral agents -- Synthesis
  • Silicon compounds
Date of Defense 2006-03-30
Availability unrestricted
Dissertation under the direction of Professor David Wilson Wright

The fusion protein of the recently discovered human metapneumovirus (hMPV) was shown to be a homolog of previously characterized type I integral membrane fusion proteins. Computer models were generated to study structural aspects of the fusion protein and identify potential antagonists. Synthetic peptides from the heptad repeat regions were also shown to possess anti-viral activity. Unlike analogous HR-1 peptides from other viruses, the hMPV HR-1 peptide proved to be a very potent inhibitor with an EC50 ~ 46 nM. The synthesis of several hundred peptides for collaborative endeavors and the ‘difficult’ sequences of the heptad repeat regions led to the study of ionic liquids as potential solvents to address aggregation and other synthetic hurdles currently cleared by expensive and labor intensive methods. Concurrently, new biologically active materials comprised of functional enzymes encapsulated in SiO2 were synthesized and characterized with an eye towards these novel materials being used as synthetic reagents.

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