Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease
Zachman, Angela Laurie
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2014-04-07
Abstract
Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to promote collateral blood vessel formation, with a low degree of inflammation to minimize plaque development. However, these two processes are intrinsically linked and difficult to uncouple. Therefore, the overarching goal of this research was to develop a biomaterial system that enables controlled, dual delivery of pro-angiogenic and anti-inflammatory peptides in minimally-invasive way. To achieve the goal, a peptide-loaded injectable scaffold system was developed and tested in a mouse model of PAD. In addition, the mechanism of peptide-mediated regulation of angiogenesis and inflammation was elucidated. By regulating pathways involved in inflammation and angiogenesis independently, this dual peptide-loaded injectable scaffold system may significantly improve recovery of ischemic tissues in patients with PAD.