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Title page for ETD etd-03312014-183105

Type of Document Dissertation
Author Zachman, Angela Laurie
URN etd-03312014-183105
Title Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Hak-Joon Sung, Ph.D. Committee Chair
Craig L. Duvall, Ph.D. Committee Member
Melissa C. Skala, Ph.D. Committee Member
Pampee P. Young, M.D., Ph.D. Committee Member
Scott A. Guelcher, Ph.D. Committee Member
  • inflammation
  • injectable polymer
  • atherosclerosis
  • peripheral artery disease
  • peptide
  • angiogenesis
Date of Defense 2014-05-24
Availability unrestricted
Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to promote collateral blood vessel formation, with a low degree of inflammation to minimize plaque development. However, these two processes are intrinsically linked and difficult to uncouple. Therefore, the overarching goal of this research was to develop a biomaterial system that enables controlled, dual delivery of pro-angiogenic and anti-inflammatory peptides in minimally-invasive way. To achieve the goal, a peptide-loaded injectable scaffold system was developed and tested in a mouse model of PAD. In addition, the mechanism of peptide-mediated regulation of angiogenesis and inflammation was elucidated. By regulating pathways involved in inflammation and angiogenesis independently, this dual peptide-loaded injectable scaffold system may significantly improve recovery of ischemic tissues in patients with PAD.
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