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Title page for ETD etd-03262012-133714

Type of Document Master's Thesis
Author Boronyak, Steven Michael
Author's Email Address steven.m.boronyak@vanderbilt.edu
URN etd-03262012-133714
Title Development of a Simultaneous Cryo-Anchoring and Radiofrequency Ablation Catheter for Percutaneous Treatment of Mitral Valve Prolapse
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
W. David Merryman Committee Chair
Robert L. Galloway Committee Co-Chair
  • radiofrequency ablation
  • mitral valve prolapse
  • heart valve mechanics
  • cryo-ablation
  • infrared thermal imaging
Date of Defense 2012-03-26
Availability unrestricted
Mitral valve prolapse is one subtype of mitral valve disease and is characterized by enlarged leaflets that are often thickened and have disrupted collagen architecture. The increased surface area of leaflets with mitral valve prolapse leads to mitral regurgitation, and there is need for percutaneous treatment options that avoid open-chest surgery. Radiofrequency ablation is one potential therapy in which resistive heating can be used to reduce leaflet size via collagen contracture. One challenge of using radiofrequency ablation to percutaneously treat mitral valve prolapse is maintaining contact between the radiofrequency ablation catheter tip and a functioning mitral valve leaflet. To meet this challenge, a radiofrequency ablation catheter was developed with a cryogenic anchor for attachment to leaflets. The effectiveness of the dual-energy catheter was demonstrated in vitro by examining changes in leaflet biaxial compliance, thermal distribution with infrared imaging, and cryogenic anchor strength. The results indicate that a catheter having combined radiofrequency ablation and cryo-anchoring provides a novel percutaneous treatment strategy for mitral valve prolapse.
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