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Title page for ETD etd-03252014-113144

Type of Document Master's Thesis
Author Kelm, Nathaniel David
Author's Email Address nathaniel.d.kelm@vanderbilt.edu
URN etd-03252014-113144
Title High Resolution 3D Diffusion Kurtosis Imaging of Whole Rat Brain
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Mark D. Does Committee Chair
Adam Anderson Committee Member
  • high resolution
  • magnetic resonance imaging
  • diffusion kurtosis imaging
  • ultra-high field
  • ex vivo rat brain
Date of Defense 2014-03-25
Availability unrestricted
This thesis involves the development of an overnight high-resolution 3D diffusion kurtosis imaging protocol for ex vivo whole rat brain imaging. MRI acquisition parameters were optimized in order to obtain high-resolution, high-precision diffusion kurtosis imaging data. This included the programming and development of a 3D diffusion-weighted fast spin-echo pulse sequence. Image data from ex vivo rat brains were collected to verify the efficacy of the imaging protocol. Values of diffusion kurtosis parameters in normal rat brains were similar to those reported in previous imaging studies. Using this protocol, preliminary data were collected from a model of schizophrenia in rats. These data indicated the ability of the protocol to detect changes in diffusion kurtosis parameters that could correlate to changes in white matter microstructure.
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