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Title page for ETD etd-03252013-092750

Type of Document Master's Thesis
Author Manhard, Mary Katherine
Author's Email Address mary.k.manhard@vanderbilt.edu
URN etd-03252013-092750
Title Validation of Quantitative Bound and Pore Water Imaging in Cortical Bone
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Mark D. Does Committee Chair
Adam Anderson Committee Member
  • 3T and 4.7T
  • ultra-short MRI
  • cortical bone
  • adiabatic inversion
Date of Defense 2013-05-10
Availability unrestricted
Clinically compatible ultra-short echo time (UTE) imaging sequences for quantitative T2-based bound and pore water imaging in bone were implemented and validated on a 3T human scanner and a 4.7T small bore system. Pore water images were generated by selectively saturating bound water signals with a T2-selective double adiabatic inversion pulse. Bound water images were generated by nulling the pore water signals with a T2-selective adiabatic inversion recovery preparation. In both cases, the magnetization preparation was integrated into a 3D UTE acquisition, with 16 radial spokes acquired per preparation. Images were acquired from human cadaveric femoral mid-shafts, from which isolated bone samples were subsequently extracted for non-imaging analysis using T2 spectroscopic measurements. The results showed a strong correlation between imaging-derived concentrations of bound and pore water and those determined from the isolated bone samples.
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