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Title page for ETD etd-03202019-113243


Type of Document Dissertation
Author Barke, Theresa Leigh
URN etd-03202019-113243
Title The Intersection of Maternal Inflammatory Stress and the Developmental Origins of Health and Disease
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
Leslie Crofford Committee Chair
Alyssa Hasty Committee Member
Eric Skaar Committee Member
Luc Van Kaer Committee Member
Keywords
  • Sexual Dimorphism
  • Placental Macrophage
  • Gestational Diabetes
  • Maternal Immune Activation
  • Reproductive Immunology
Date of Defense 2018-12-18
Availability unrestricted
Abstract
The most important factor influencing the prenatal environment is the maternal environment. There is a growing body of evidence suggesting that the maternal and intrauterine milieu, through the action of inflammatory mediators may permanently change the health of the fetus. Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy and is associated with aberrant systemic inflammation and known to cause considerable morbidity, mortality, and long-term complications for both mother and child. Maternal immune activation (MIA), another prenatal insult, is common and occurs as the result of an infection during pregnancy. Several epidemiological as well as clinical studies have shown associations between infection and MIA during pregnancy and an increased risk for developing neurocognitive disorders such as autism and schizophrenia in offspring. The aberrant inflammation caused by GDM and maternal obesity is also gaining evidence as a possible cause for the same neurocognitive disorders. For progress to be made in the prevention and treatment of these disorders it is important to identify both the biological and environmental factors underlying disorder pathogenesis. Several transcriptional changes within the placenta and fetal brain were identified as a result of GDM, MIA, and the combination of the two. Within the placenta, many of these changes were dependent upon the sex of the fetus.
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