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Title page for ETD etd-03192018-100046


Type of Document Dissertation
Author Simon, David Michael
URN etd-03192018-100046
Title Electrophysiological Signatures of Multisensory Temporal Processing in the Human Brain
Degree PhD
Department Neuroscience
Advisory Committee
Advisor Name Title
Geoffrey Woodman Committee Chair
Frank Tong Committee Member
Mark Wallace Committee Member
Ramnaryan Ramachandran Committee Member
Keywords
  • Event Related Potentials
  • EEG
  • Speech
  • Audiovisual
  • Multisensory
  • Temporal
Date of Defense 2018-03-12
Availability unrestricted
Abstract
NEUROSCIENCE

Electrophysiological Signatures of Multisensory Temporal Processing

in the Human Brain

David Michael Simon

Dissertation under the direction of Professor Mark T. Wallace

Events in the natural world frequently generate sensory signals in more than one sensory modality. Multisensory integration, the process of combining these signals into a single coherent perceptual representation, conveys numerous behavioral and perceptual benefits. Integration of audiovisual inputs is particularly relevant to everyday function, as many ecologically important signals such as speech have both auditory and visual elements. To accomplish appropriate integration of audiovisual speech inputs, the nervous system utilizes a number of cues, one of which is the temporal relationship between the auditory and visual signals. We investigated the neurophysiological bases of how the brain uses temporal information to appropriately integrate audiovisual speech inputs using a combination of psychophysics and electroencephalography (EEG). This series of investigations elucidated that, for ecologically valid speech signals, the brain uses temporal concordance to reduce the magnitude of auditory cortical responses and increase the efficiency of cortical processing. Furthermore, we demonstrate that when temporal relationships are task relevant, the neural signals associated with temporal processing are distributed to other brain regions through the formation of functional neural networks. Lastly, perceptual plasticity at the single trial level during temporal processing was found to be associated with changes in the physiological signatures of sensory evidence accumulation in decisional circuits. These experiments offer unique insights into how the brain utilizes temporal concordance to control multiple levels of sensory integration which span low-level cortical responses, transfer of temporal information to higher cognitive systems, and the formation of flexible perceptual decisions. Together they offer the first comprehensive physiological characterization of audiovisual temporal processing in the human brain.

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