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Title page for ETD etd-03112019-120219


Type of Document Dissertation
Author Perry-Hauser, Nicole Anna
URN etd-03112019-120219
Title Arrestins: multifunctional regulators of signaling pathways
Degree PhD
Department Pharmacology
Advisory Committee
Advisor Name Title
Dr. Benjamin Spiller Committee Chair
Dr. Annette G. Beck-Sickinger Committee Member
Dr. Raymond Blind Committee Member
Dr. Tina M. Iverson Committee Member
Dr. Vsevolod V. Gurevich Committee Member
Keywords
  • signaling
  • scaffold
  • mitogen-activated protein kinase cascades
  • G protein-coupled receptors
  • arrestin
Date of Defense 2019-03-04
Availability restricted
Abstract
The four vertebrate arrestins comprise a family of proteins that are responsible for the desensitization and internalization of over 800 subtypes of G protein-coupled receptors (GPCRs). The arrestins also serve as independent signal transducers in both a receptor-dependent and receptor-independent fashion. The nonvisual arrestins (arrestin-2 and arrestin-3, or β-arrestin-1 and β-arrestin-2) have been shown to interact with >100 signaling and trafficking proteins. In particular, the arrestins are well-characterized for their role in the scaffolding of several mitogen-activated protein kinase (MAPK) cascades. Over the course of my thesis work, I investigated the mechanisms underlying arrestin-mediated scaffolding and activation of these cascades with a specific focus on the JNK3 and ERK2 cascades.
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