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Title page for ETD etd-01162019-091326


Type of Document Dissertation
Author Wilson, Christopher Scott
URN etd-01162019-091326
Title New Modes of B lymphocyte Regulation in Autoimmune Disease
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
James W. Thomas Committee Chair
Daniel J. Moore Committee Member
Jonathan M. Irish Committee Member
Mark R. Boothby Committee Member
William E. Russell Committee Member
Keywords
  • B cells
  • Type 1 Diabetes
  • Tolerance
  • Immunology
Date of Defense 2018-12-18
Availability restrictsix
Abstract
New Modes of B lymphocyte Regulation in Autoimmune Disease

Christopher Scott Wilson

Dissertation under the direction of Professor Daniel J. Moore

The deleterious roles that B lymphocytes play in autoimmunity and regulation of immune

tolerance are well documented in the literature. B lymphocytes are thought to mediate autoimmunity primarily through presentation of autoantigens to T lymphocytes. Targeting B lymphocytes by depletion clinically in autoimmune disease has been attempted with varying levels of success. The failure of current clinical approaches may be the result of a deficit in our understanding of the role of B lymphocytes in autoimmune disease. B lymphocytes possess multiple functions which, depending on context, may mediate distinct immunologic outcomes. Certain instances have indicated that B lymphocytes can mediate immune regulation. Targeting B lymphocyte function and homeostasis in autoimmune disease revealed novel ways that B lymphocyte regulate organ damage and reverse autoimmune disease. This work highlights new ways to foster B lymphocyte regulation of autoimmune disease.

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