Type of Document Dissertation Author Wilson, Christopher Scott URN etd-01162019-091326 Title New Modes of B lymphocyte Regulation in Autoimmune Disease Degree PhD Department Microbiology and Immunology Advisory Committee
Advisor Name Title James W. Thomas Committee Chair Daniel J. Moore Committee Member Jonathan M. Irish Committee Member Mark R. Boothby Committee Member William E. Russell Committee Member Keywords
- B cells
- Type 1 Diabetes
Date of Defense 2018-12-18 Availability restrictsix AbstractNew Modes of B lymphocyte Regulation in Autoimmune Disease
Christopher Scott Wilson
Dissertation under the direction of Professor Daniel J. Moore
The deleterious roles that B lymphocytes play in autoimmunity and regulation of immune
tolerance are well documented in the literature. B lymphocytes are thought to mediate autoimmunity primarily through presentation of autoantigens to T lymphocytes. Targeting B lymphocytes by depletion clinically in autoimmune disease has been attempted with varying levels of success. The failure of current clinical approaches may be the result of a deficit in our understanding of the role of B lymphocytes in autoimmune disease. B lymphocytes possess multiple functions which, depending on context, may mediate distinct immunologic outcomes. Certain instances have indicated that B lymphocytes can mediate immune regulation. Targeting B lymphocyte function and homeostasis in autoimmune disease revealed novel ways that B lymphocyte regulate organ damage and reverse autoimmune disease. This work highlights new ways to foster B lymphocyte regulation of autoimmune disease.
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