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Title page for ETD etd-12272015-153630


Type of Document Dissertation
Author Siemann, Justin Kyle
URN etd-12272015-153630
Title Evaluating Multisensory Processing in the Mouse Model: Clinical and Translational Implications
Degree PhD
Department Neuroscience
Advisory Committee
Advisor Name Title
James Bodfish Committee Chair
Beth Malow Committee Member
Jeremy Veenstra-VanderWeele Committee Member
Mark Wallace Committee Member
Stephen Camarata Committee Member
Keywords
  • mouse models
  • serotonin
  • mouse behavior
  • visual processing
  • autism spectrum disorders
  • multisensory integration
  • auditory processing
Date of Defense 2015-12-07
Availability restricted
Abstract
NEUROSCIENCE

Evaluating Multisensory Processing in the Mouse Model: Clinical and Translational Implications

Justin Kyle Siemann

Dissertation under the direction of Mark T. Wallace

Multisensory integration is the synthesis of information from the different sensory systems. Numerous investigations have evaluated multisensory function in humans and in various animal models with these studies demonstrating significant neural, behavioral and perceptual benefits conferred under multisensory conditions. In addition, emerging studies have described atypical multisensory function in clinical populations such as those with autism spectrum disorder. While a variety of animal models have been used to assess multisensory processing, there were no current behavioral tasks available for the mouse model. Here, we demonstrate the first behavioral paradigm to assess and evaluate multisensory processing in the mouse, and which show similar behavioral benefits as compared to larger animal species. In addition, we then demonstrate the first characterization of atypical multisensory behavioral function in a mouse model associated with autism spectrum disorder. Lastly, we observed that depending on the type of behavioral task implemented, mice can demonstrate vastly different behavioral responses under these multisensory conditions. Overall, we describe a series of novel studies that examine and characterize multisensory behavioral function in the mouse model system with the belief that this work may provide opportunities for further insights into the underlying neural mechanisms of multisensory function in both typical development and in autism spectrum disorder.

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