A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-12102009-163623

Type of Document Master's Thesis
Author Paras, Constantine A
Author's Email Address dean.paras@vanderbilt.edu
URN etd-12102009-163623
Title A novel optical approach to the intraoperative detection of parathyroid glands
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Dr. Anita Mahadevan-Jansen Committee Member
  • anatomic guidance
  • Near-infrared autofluorescence
  • parathyroid
Date of Defense 2009-12-10
Availability unrestricted
A major challenge in endocrine surgery is the intraoperative identification of parathyroids during both thyroid and parathyroid surgery. Current localization techniques are mostly preoperative and are imprecise. Optical spectroscopy is fast and sensitive and has been used in many in vivo applications. Here, near-infrared (NIR) fluorescence is used to identify parathyroid glands during thyroid and parathyroidectomies. We investigated whether parathyroid tissue had unique optical signals that could be used to identify the parathyroid glands and differentiate them from other tissues in the neck intra-operatively. Fluorescence measurements were obtained from patients undergoing endocrine surgery at Vanderbilt University Medical Center. The intensity of the parathyroid signal was compared to the fluorescence of the surrounding tissue including the thyroid gland. In each case, the parathyroid had markedly higher levels of fluorescence. These results indicate that NIR fluorescence is potentially an excellent tool to locate parathyroid tissue during surgery.
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Masters_Constantine_Paras.pdf 439.39 Kb 00:02:02 00:01:02 00:00:54 00:00:27 00:00:02

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.