A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-12062007-124455


Type of Document Master's Thesis
Author Lorang, Craig Thomas
Author's Email Address craig.t.lorang@vanderbilt.edu
URN etd-12062007-124455
Title Using Diffusion Tensor Imaging to Assess White Matter Integrity in Children with Math Difficulties
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Adam Anderson Committee Member
Keywords
  • Diffusion tensor imaging
  • math difficulties
  • Acalculia in children
  • Brain -- Magnetic resonance imaging
Date of Defense 2007-12-07
Availability unrestricted
Abstract
USING DIFFUSION TENSOR IMAGING TO ASSESS WHITE MATTER

INTEGRITY IN CHILDREN WITH MATH DIFFICULTIES

CRAIG THOMAS LORANG

Thesis under the direction of Professor Adam Anderson

Dyscalculia is a learning disability that interferes with a person’s ability to understand and manipulate numbers. This condition affects up to 6% of all children. Previous studies have shown cortical functional activation in the parietal lobe related to number processing, however no studies have investigated the relationship between white matter integrity and number processing. Thirty-three subjects (mean age: 9.6 years) were imaged using a 3 Tesla Philips Achieva MRI scanner. Anatomical and diffusion weighted datasets were pre-processed and registered to a common space. Fractional anisotropy maps were mapped into the common space. Group t-tests were performed on a voxel-by-voxel basis on the FA maps between control and math difficulty (MD) groups. Linear correlations were performed on a voxel-by-voxel basis between FA and Wide Range Achievement Test – Third Edition (WRAT) performance in the math and reading subtests. Regions in the left parietal and occipital lobes were found to have FA values correlating with math performance. A frontal lobe region was found to correlate with both reading and math performance, suggesting these two complex operations share portions of white matter bundles. These findings suggest white matter disorganization in regions critical for number processing. Further investigation will be needed to determine if intervention can change the developmental trajectory of these white matter pathways.

Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Masters_paper.pdf 4.73 Mb 00:21:53 00:11:15 00:09:51 00:04:55 00:00:25

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.