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Title page for ETD etd-12052015-165628


Type of Document Dissertation
Author Suarez, Sandra
Author's Email Address sandrasuarez4@gmail.com
URN etd-12052015-165628
Title An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis
Degree PhD
Department Cell and Developmental Biology
Advisory Committee
Advisor Name Title
John J. Reese Committee Chair
David M. Miller Committee Member
Douglas G. McMahon Committee Member
John S. Penn Committee Member
Sandra S. Zinkel Committee Member
Keywords
  • Diabetic retinopathy
  • cell death
  • apoptosis
  • high glucose
  • GAPDH
  • Siah1
  • cell signaling
Date of Defense 2015-12-04
Availability restricted
Abstract
Diabetic Retinopathy (DR) is a leading cause of blindness worldwide, and its prevalence is growing. Current therapies for DR address only the later stages of the disease, are invasive and are of limited effectiveness. Retinal pericyte death is an early pathologic
feature of DR. Though it has been observed in diabetic patients and in animal models of DR, the cause of pericyte death remains unknown. A novel pro-apoptotic pathway initiated by the interaction between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the E3 ubiquitin ligase, seven in absentia homolog 1 (Siah1), was identified to play a significant role in human retinal pericyte apoptosis. Inhibition of the GAPDH/Siah1 pro-apoptotic complex blocks diabetes-induced pericyte apoptosis, widely considered a hallmark feature of DR.
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