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Title page for ETD etd-12022008-205835


Type of Document Dissertation
Author Burnum, Kristin Elizabeth
Author's Email Address keburnum@aol.com
URN etd-12022008-205835
Title Detecting spatial and temporal distributions of lipids and proteins during embryo implantation by MALDI Imaging Mass Spectrometry
Degree PhD
Department Biochemistry
Advisory Committee
Advisor Name Title
Richard M. Caprioli Committee Chair
Daniel C. Liebler Committee Member
H. Alex Brown Committee Member
Jennifer A. Pietenpol Committee Member
Michael R. Waterman Committee Member
Keywords
  • Imaging Mass Spectrometry
  • Embryo Implantation
Date of Defense 2008-10-23
Availability unrestricted
Abstract
Molecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies to elucidate the spatial patterning of lipids and proteins during embryo implantation and demonstrate its value in helping to understand fertility and the reproductive process. For example, our analysis clearly shows previously unknown molecular distributions of lipids over time in this system. Beyond this example, we think that the approach and the concepts illustrated in this work will be of value in various areas of biology and will be critical for understanding many biological processes.
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