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Title page for ETD etd-11292012-144810


Type of Document Dissertation
Author Rao, Meghana Nallamala
URN etd-11292012-144810
Title The Role of VAPB in Breast Cancer
Degree PhD
Department Cancer Biology
Advisory Committee
Advisor Name Title
Albert Reynolds Committee Chair
Jin Chen Committee Member
Rebecca Cook Committee Member
Robert Coffey Committee Member
Keywords
  • cancer
  • breast
  • VAPB
  • secretion
  • AKT
Date of Defense 2012-10-18
Availability unrestricted
Abstract
VAPB (VAMP-associated protein B) is an endoplasmic reticulum protein that regulates multiple biological functions. VAPB protein expression is elevated in human breast cancers and correlates with poor prognosis. Despite aberrant expression of VAPB in breast cancer, its function in tumor cells is poorly understood. In this dissertation we demonstrate the causal role between VAPB and breast cancer, specifically in three areas (1) cell growth (2) invasion and (3) tumor growth in vivo. Additionally, we provide mechanistic evidence that VAPB regulates breast tumor cell proliferation and invasion through enhanced ATK activity and vesicle mediated protein secretion.
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