A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-11212011-105343


Type of Document Dissertation
Author Mitchell, Amanda Christine
Author's Email Address acmelle@gmail.com
URN etd-11212011-105343
Title Identifying Physical Activity-Associated Neuroprotective Gene Transcripts
Degree PhD
Department Neuroscience
Advisory Committee
Advisor Name Title
Christine Konradi Committee Chair
Aaron Bowman Committee Member
Judy L. Cameron Committee Member
Karoly Mirnics Committee Member
Keywords
  • physical activity
  • exercise
  • Parkinsons disease
  • MPTP
  • Rhesus monkey
  • gene expression
  • caudate
  • hippocampus
  • motor cortex
  • putamen
  • neuroprotection
Date of Defense 2011-11-11
Availability unrestricted
Abstract
Mild, moderate, and vigorous physical activity are associated with decreased risks of Alzheimerís disease, Parkinsonís disease, and a decreased infarct from stroke. Physical activity increases neurogenesis in the hippocampus and upregulates neurotrophic factors throughout the brain, but it largely has been understudied in motor brain regions related to Parkinsonís disease. We hypothesized that aerobic exercise would be protective against a MPTP lesion in Rhesus monkeys. We used three cohorts of monkeys to study gene expression associated with physical activity and exercise in motor regions of the brain: (1) spontaneously physically active rhesus monkeys, (2) exercised rhesus monkeys, and (3) spontaneously physically active and exercised rhesus monkeys before and after receiving a MPTP lesion. We found that physical activity as measured by accelerometers predicts the size the MPTP lesion, as monkeys with high levels of physical activity were protected from the lesion. Furthermore, the activity-associated neuroprotective gene expression signature involved transcripts associated with chromatin remodeling, neuronal survival, and specifically syntaxin 3. These studies suggest that being physically active is protective against Parkinsonís disease.
Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  MitchellA_DS_Final.pdf 12.19 Mb 00:56:27 00:29:01 00:25:24 00:12:42 00:01:05

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.