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Title page for ETD etd-11172010-081943


Type of Document Dissertation
Author Loveless, Mary E
Author's Email Address mary.loveless@vanderbilt.edu
URN etd-11172010-081943
Title Optimization, Application, and Cross-correlation of DCE-MRI in Small Animal Models of Cancer
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Thomas E. Yankeelov Committee Chair
Christopher C. Quarles Committee Member
J. Oliver McIntyre Committee Member
John C. Gore Committee Member
Mark Does Committee Member
Keywords
  • cancer
  • MRI
  • DCE-MRI
Date of Defense 2010-10-28
Availability unrestricted
Abstract
With cancer encompassing a range of disease states and phenotypes, assessing treatment efficacy early, accurately, and non-invasively is essential to optimize therapy planning on an individualized basis. This work discusses two types of cancer imaging techniques, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI), and the importance they have to several classes of drug treatment regimens. Additionally, this work optimizes and identifies errors in current protocols used in preclinical MRI studies of anti-cancer therapies. These optimized protocols were then used to assess the efficacy of a novel anti-cancer treatment early in the course of therapy. Finally, the relationship between two MR imaging biomarkers frequently used in monitoring cancer therapy were assessed and compared to histology.
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