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Title page for ETD etd-11102008-012303


Type of Document Dissertation
Author Xia, Yuanfeng
URN etd-11102008-012303
Title Molecular and cellular studies of mosquito odorant receptors and olfactory-driven larval behavior
Degree PhD
Department Biological Sciences
Advisory Committee
Advisor Name Title
Clint E Carter Committee Chair
Bruce Appel Committee Member
James G. Parton Committee Member
Laurence J Zwiebel Committee Member
Ronald Emeson Committee Member
Keywords
  • Smell -- Molecular aspects
  • Chemoreceptors
  • Mosquitoes as carriers of disease
  • Neuroscience; Olfaction; Mosquito; Malaria
  • Mosquitoes -- Larvae
  • Mosquitoes -- Sense organs
Date of Defense 2008-07-15
Availability unrestricted
Abstract
This thesis is concerned with the study of olfactory systems in both larval and adult mosquitoes. In this dissertation I cloned the first odorant receptor from mosquito Culex quinquefasciatus and localized the receptor proteins to the olfactory organs of the mosquito. By utilizing a sensitive behavioral assay, I also identified a range of odorant-specific responses that are dependent on the integrity of the Anopheles gambiae larval antennae. Parallel molecular studies further identified a subset of odorant receptors localized to larval antennae and these receptors could confer responses to all behaviorally active compounds when expressed in xenopus oocytes. My research may ultimately enhance the development of vector control strategies, targeting olfactory pathways in both larval and adult mosquitoes to reduce the catastrophic effects of malaria and other mosquito-borne diseases.
Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Dissertation.pdf 3.42 Mb 00:15:49 00:08:08 00:07:07 00:03:33 00:00:18

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