A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-11082004-203228


Type of Document Dissertation
Author Blodgett, Jordan Danielle
URN etd-11082004-203228
Title Novel methods in chromatographic separations: new chiral stationary phases and molecular tagging
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
David M. Hercules Committee Chair
David W. Wright Committee Member
Ned A. Porter Committee Member
Prasad Polavarapu Committee Member
Keywords
  • chiral chromatography
  • separation tagging
  • solid phase synthesis
Date of Defense 2004-11-04
Availability unrestricted
Abstract
CHEMISTRY

NOVEL METHODS IN CHROMATOGRAPHIC SEPARATIONS:

NEW CHIRAL STATIONARY PHASES AND

MOLECULAR TAGGING

JORDAN DANIELLE HANEY BLODGETT

Dissertation under the direction of Professor David M. Hercules

A major obstacle for many chemists is the retrieval of desired compounds from a mixture resulting from a chemical reaction or from a complex analytical sample. Even more challenging is the need to separate enantiomers of the same compound from each other. In the past the determination of chiral selectors for chiral HPLC has largely been an empirical process requiring large amounts of time in order to develop new selectors for difficult separations. It is therefore of great importance to pursue methods for faster screening of selectors for a given analyte. We report a powerful method for the screening of peptide-based chiral selectors in a high-throughput manner using parallel combinatorial library technology. In addition, since the practical synthesis of organic compounds is limited not only by yield of specific reactions but also by the ability to isolate products efficiently, strategies to facilitate product isolation are an important development. A new tagging system based on the interaction of beta-cyclodextrin and the 4-tert-butylphenyl group will be described to address this need.

Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  JordanBlodgettdissertation.pdf 1.01 Mb 00:04:41 00:02:24 00:02:06 00:01:03 00:00:05

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.