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Title page for ETD etd-09282009-041526


Type of Document Dissertation
Author Sarangi, Anuraag
Author's Email Address anuraag.sarangi@gmail.com
URN etd-09282009-041526
Title Identification of the Hedgehog pathway as a novel therapeutic target in malignant gliomas
Degree PhD
Department Neuroscience
Advisory Committee
Advisor Name Title
Chin Chiang Committee Chair
Michael K. Cooper Committee Co-Chair
Bruce Appel Committee Member
Harold L. Moses Committee Member
Mark deCaestecker Committee Member
Keywords
  • cancer stem cells
  • CD133
  • cyclopamine
  • brain cancer
  • hedgehog
  • glioma
Date of Defense 2009-08-21
Availability unrestricted
Abstract
Gliomas are the predominant type of primary central nervous system tumors. They are highly invasive and notoriously refractory to current therapies. Patients diagnosed with a malignant glioma face a dismal prognosis that has remained relatively unchanged in the last three decades. A promising novel approach to glioma therapy is based upon modulating molecular mechanisms that regulate cell types critical for tumor growth. Recent identification of cancer stem cells that initiate and maintain tumor growth in gliomas has prompted investigation into the molecular signaling pathways that regulate this unique cell type. The Hedgehog (Hh) signaling pathway regulates stem cells and is activated in several cancer types. Prompted by the role of Hh signaling in regulating neural stem cell self-renewal, I investigated the potential role of the pathway in glioma growth. To address this question, I evaluated the status of Hh signaling in primary gliomas. Furthermore, I tested our hypothesis that Hh signaling regulates glioma growth in a relevant preclinical model.
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