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Title page for ETD etd-09222009-120914


Type of Document Dissertation
Author Johnson, Elizabeth Rose Meade
Author's Email Address elizabeth.m.johnson@vanderbilt.edu
URN etd-09222009-120914
Title The Role of Cathepsin Proteases in Reovirus Pathogenesis
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
Terence Dermody Committee Chair
Anne Kenworthy Committee Member
Borden Lacy Committee Member
Graham Carpenter Committee Member
Mark Boothby Committee Member
Keywords
  • viral pathogenesis
  • virus
  • reovirus
  • cathepsin
Date of Defense 2009-08-05
Availability unrestricted
Abstract
The cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells. Mammalian reoviruses utilize cathepsins B, L, and S for disassembly of the virus outer capsid and activation of the membrane-penetration machinery. Studies using mice deficient for cathepsin B, L, or S revealed that these enzymes influence reovirus pathogenesis. Furthermore, pharmacologic modulation of cathepsin activity attenuates reovirus disease. These findings have broad implications for the role of cathepsin proteases in viral infections and suggest that cathepsin inhibitors should be developed as therapeutics.
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