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Title page for ETD etd-08222017-072112


Type of Document Dissertation
Author Stier, Matthew Tyler
Author's Email Address matthew.stier@vanderbilt.edu
URN etd-08222017-072112
Title The Role of Innate Lymphoid Cells in Pulmonary Viral Infection and Allergic Inflammation
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
Mark Boothby Committee Chair
Eric Sebzda Committee Member
John Williams Committee Member
Peggy Kendall Committee Member
R. Stokes Peebles Jr. Committee Member
William Lawson Committee Member
Keywords
  • ILC2
  • RSV
  • IL-33
  • TSLP
Date of Defense 2017-07-31
Availability restricted
Abstract
Airway inflammatory diseases including viral bronchiolitis and allergy are significant causes or morbidity and mortality worldwide. A recently identified lineage of leukocytes known as innate lymphoid cells (ILC) have potent inflammatory potential, but their mechanistic role in airway inflammation is not entirely understood. Group 2 ILC were identified to be activated in a mouse model of severe respiratory syncytial virus (RSV) infection and correlated with significant pathophysiologic changes in the airways including mucus production. That activation depended upon the cytokine thymic stromal lymphopoietin (TSLP). Broadly, group 1, 2, and 3 ILC responses were coordinated by signal transducer and activator of transcription 1 (STAT1), which promoted group 1 ILC and restricted group 2 and 3 ILC during RSV infection. Finally, IL-33 signaling mediated egress of ILC2 from the bone marrow during initial seeding of tissues in the post-natal period as well as in the context of allergic inflammation. These data broadly support a role for ILC2 in the pathogenesis of respiratory viral infection and provide mechanistic insights into how ILC2 egress from the bone marrow to support allergic inflammation.
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