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Title page for ETD etd-08112015-104456


Type of Document Dissertation
Author O'Neil, Richard Thomas
Author's Email Address richard.t.oneil@vanderbilt.edu
URN etd-08112015-104456
Title Exploring the dynamics of A-to-I editing in the mammalian brain
Degree PhD
Department Neuroscience
Advisory Committee
Advisor Name Title
Karoly Mirnics Committee Chair
Gregg Stanwood Committee Member
Roger Cone Committee Member
Ronald B Emeson Committee Member
Keywords
  • RNA
  • Inosine
Date of Defense 2015-04-21
Availability unrestricted
Abstract
Adenosine-to-Inosine RNA editing (A-to-I editing) has evolved as an important process for generating transcript diversity in metazoans. Several editing events which effect transcripts encoding proteins important for CNS function appear to be conserved in mammals, however the precise role these RNA editing events play in regulating physiology and behavior are not clear. The major goal of this work is to identify circumstances that lead to dynamic variations in the expression of different edited transcript isoforms within the mammalian brain in order to gain insights about the regulation and function of A-to-I editing in mammals. The results of these studies challenge popular models of dynamic editing at transcripts encoding 5HT2C receptors while providing new information about conserved global and context dependent patterns of A-to-I editing at various substrates in the mammalian brain. Furthermore, this work evaluates the roles of RNA processing of 5HT2C transcripts in the human genetic disorder Prader-Willi Syndrome (PWS).
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