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Title page for ETD etd-08102011-144255


Type of Document Dissertation
Author Collins, Patrick Leonard
Author's Email Address patlennycollins@yahoo.com
URN etd-08102011-144255
Title Distal regulation of the interferon gamma locus
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
Anthony Weil Committee Member
Eric Sebzda Committee Member
Luc Van Kaer Committee Member
Tom Aune Committee Member
Wonder Drake Committee Member
Keywords
  • T helper
  • Th1
  • NK
  • Natural Killer
  • Cytokine
  • CD4
Date of Defense 2011-07-19
Availability unrestricted
Abstract
In metazoans, developmentally regulated genes depend upon cis-regulatory elements for cell-type specific and heritable transcription. By employing a BAC transgenic system, I demonstrate the function of the noncoding region of the human interferon-gamma (IFNG) locus. Deletion of individual IFNG regulatory elements results in cell-type specific loss of gene expression, stimulus-specific gene up regulation, or loss of expression in suboptimal conditions. These results demonstrate that appropriate cell and stimulus specific expression of IFNG is achieved through the interactions of multiple unique distal regulatory elements.
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