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Title page for ETD etd-07282014-234021


Type of Document Master's Thesis
Author Ovchinnikov, Oleg Sergeeivch
URN etd-07282014-234021
Title Developing a high sensitivity and spatial resolution SPECT molecular imaging system through the use of novel multiplexing
Degree Master of Science
Department Physics
Advisory Committee
Advisor Name Title
Dr. Todd E. Peterson Committee Chair
Dr. A. S. Umar Committee Member
Keywords
  • pinhole
  • SPECT
Date of Defense 2014-08-01
Availability unrestricted
Abstract
Molecular imaging is an important tool in both clinical and pre-clinical settings. Single Photon Emission Computed Tomography (SPECT) is a molecular imaging technique provides important information for everything from medical diagnoses in the hospital to looking at the spatial distribution of drugs in the body. However, current SPECT systems consisting of collimation in conjunction with a gamma emission require high radiation doses to be administered to achieve the desired imaging resolution because of the low sensitivity. In order to improve on both imaging resolution and sensitivity in SPECT without increasing the radiation dose given to a patient different detector designs must be examined. The overarching goal of this project was the development of a novel SPECT detector design using synthetic collimation combined with high levels of multiplexing to increase imaging resolution and sensitivity while allowing for lower radiation doses to subjects. A silicon detector enclosure was designed that allowed for a stacked configuration with the silicon detector mounted between the collimator and a germanium detector. Initial testing of this unique camera was performed, and a method for designing an optimized multi-pinhole collimator for this synthetic collimation system through the use of simulations was also developed.
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