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Title page for ETD etd-07222008-160325


Type of Document Dissertation
Author Kanter, Elizabeth Marie
URN etd-07222008-160325
Title Characterization of Raman spectroscopy for the human cervix
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Anita Mahadevan-Jansen Committee Chair
Duco E. Jansen Committee Member
Gautam Rao Committee Member
Rick Haselton Committee Member
Yu Shyr Committee Member
Keywords
  • Cervical Dyplasia
  • Raman Spectroscopy
  • optical biopsy
Date of Defense 2008-05-07
Availability unrestricted
Abstract
Raman spectroscopy has the potential for providing differential diagnosis between dysplasia and benign cervix with high sensitivity and specificity. Two in vivo studies where designed to further evaluate the potential and improve the sensitivity of Raman spectroscopy to detect cervical dysplasia in a clinical setting. In the first study, the Raman spectral differences between the low grade dysplasia, high grade dysplasia, and benign cervix were characterized with a focus on low grade dysplasia, and a multi-class algorithm was used to classify spectra. The second study characterized spectral variability of the normal cervix due to factors such as hormonal status and the presence of previous disease. Additionally, Raman micro-spectroscopy was used to evaluate differences among histopathology classes and determine where the signal from in vivo experiments originates. These studies have shown that by taking normal variations of the cervix into consideration, Raman spectroscopy can successfully differentiate low grade dysplasia, high grade dysplasia, and benign cervix with high classification accuracy.
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