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Title page for ETD etd-07222008-092825


Type of Document Dissertation
Author McBride, Krista Kay
URN etd-07222008-092825
Title High-sensitivity imaging of magnetic fields from cardiac apex action potential propagation using superconducting quantum interference device (SQUID) microscopy
Degree PhD
Department Physics
Advisory Committee
Advisor Name Title
Franz J Baudenbacher Committee Chair
Alan Bradshaw Committee Member
John P. Wikswo Committee Member
Michael I Miga Committee Member
Sait A Umar Committee Member
Keywords
  • apex
  • MCG
  • superconducting quantum interference device
  • SQUID
  • heart
  • cardiac
Date of Defense 2008-06-20
Availability unrestricted
Abstract
In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbit’s cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found that the spiral structure gives a distinct magnetic imprint that can be reproduced by monodomain and bidomain modeling.

The SQUID microscope has also been improved by implementing a lever mechanism and monolithic SQUID sensors for higher magnetic spatial resolution and sensitivity measurements.

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