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Title page for ETD etd-07202016-120256


Type of Document Master's Thesis
Author Lapierre-Landry, Maryse
Author's Email Address mlapierrelandry@gmail.com
URN etd-07202016-120256
Title Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Melissa C. Skala Committee Chair
Brett Byram Committee Member
Keywords
  • Optical coherence tomography
  • photothermal effect
  • phase-sensitive
Date of Defense 2016-07-13
Availability unrestricted
Abstract
Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT has been demonstrated in vitro, ex vivo, and in vivo on multiple contrast agents such as gold nanoparticles and indocyanine green. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithm. Past models have focused on individual components of the PT-OCT signal, but a comprehensive model still had to be assembled. We propose the first PT-OCT model to replicate an A-scan in homogeneous and layered samples. Our predictions were validated experimentally in silicone phantoms. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artefacts found in PT-OCT images and demonstrate this algorithm on phantom and in vivo images.
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