A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-07172013-085324


Type of Document Master's Thesis
Author Carrell, Holly Marie
URN etd-07172013-085324
Title Isolation and Characterization of Anti-malarial Compounds from a Natural Product Library
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
David Wright Committee Chair
Brian Bachmann Committee Member
Keywords
  • Malaria
  • drug discovery
  • natural products
  • actinomycete library
Date of Defense 2013-07-19
Availability unrestricted
Abstract
Malaria is a disease caused by the parasite Plasmodium falciparum which kills 1-2.7 million people per year. Parasite resistance to widely available anti-malarial treatments such as Chloriquine is spreading rapidly, and current treatments for Chloroquine-resistant parasites tend to be unaffordable for people in the impoverished areas where malaria is endemic. Therefore, there is an increasing need for anti-malarial treatments that are easy to develop, effective, and inexpensive. In this study, we explore a novel source of anti-malarial probes by screening extracts from a library of cave actinomycetes. Using the â-hematin formation assay optimized in the Wright lab to screen for anti-malarial activity, coupled with LC-MS and 2D NMR techniques, we can isolate active compounds and determine their structure. In this project we identify the soy isoflavone Genistein as an active anti-malaria probe, and explores a new natural product resource that may be helpful in the continuing search for novel anti-malarial treatments.
Files
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  CarrellThesis.pdf 1.54 Mb 00:07:07 00:03:40 00:03:12 00:01:36 00:00:08

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.