A joint project of the Graduate School, Peabody College, and the Jean & Alexander Heard Library

Title page for ETD etd-05272015-124610

Type of Document Dissertation
Author Kost, Susan Danica
URN etd-05272015-124610
Title Patient-Specific Dosimetry for Targeted Radionuclide Therapy Using Deformable Anthropomorphic Phantoms
Degree PhD
Department Physics
Advisory Committee
Advisor Name Title
Michael G Stabin Committee Chair
David R Pickens Committee Member
Kelly Holley-Bockelmann Committee Member
Manuel Morales-Paliza Committee Member
Ronald R Price Committee Member
W. Paul Segars Committee Member
  • patient-specific
  • Monte Carlo
  • nuclear medicine
  • dosimetry
  • medical physics
Date of Defense 2015-04-24
Availability unrestricted
The administration of open radioactive sources to systemically target malignant cells has become a desirable treatment option for several types of cancer. However, patients receiving this form of radiation therapy often do not benefit from patient-specific treatment planning that is the gold standard in patient care for external beam therapy and brachytherapy. Therapeutic absorbed doses delivered by targeted radionuclide therapy can be predicted on an individual basis with activity quantification derived from a diagnostic tracer study. The aim of performing these calculations is to optimize the tumor dose-response while limiting toxicity to normal tissue. This thesis includes the creation of a novel method for individualized dosimetry using a patient-specific organ map generated from a deformable anthropomorphic phantom. Three-dimensional dose estimates are obtained using Monte Carlo particle transport based on the Geant4 simulation toolkit. The method was validated and applied to patient studies with planning times short enough to make this approach clinical viable.
  Filename       Size       Approximate Download Time (Hours:Minutes:Seconds) 
 28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access 
  Kost_Susan_Dissertation_2015.pdf 4.50 Mb 00:20:50 00:10:43 00:09:22 00:04:41 00:00:24

Browse All Available ETDs by ( Author | Department )

If you have more questions or technical problems, please Contact LITS.