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Title page for ETD etd-04202016-114145


Type of Document Dissertation
Author Montenegro Burke, Jose Rafael
URN etd-04202016-114145
Title Enhanced separations strategies for complex sample characterization using ion mobility-mass spectrometry
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
John A. McLean Committee Chair
David E. Cliffel Committee Member
David M. Hercules Committee Member
Janet E. Macdonald Committee Member
Ned A. Porter Committee Member
Keywords
  • separations
  • ion mobility-mass spectrometry
  • complex sample
Date of Defense 2016-04-15
Availability unrestricted
Abstract
Ion mobility-mass spectrometry (IM-MS) is an analytical technique used to separate gas-phase ions based on their structural properties such as size and shape as well as their mass, in the IM and MS dimensions, respectively. Furthermore, this analytical technique has become a widely used tool for a wide variety of fields. Its great sensitivity and selectivity provides scientists numerous advantages for the analysis of complex samples of numerous analyte types (biomolecules, synthetic polymers, metals, etc.) spanning a broad dynamic range. It is well known, that MS can be greatly improved when a separation is performed prior to ionization, more commonly liquid chromatography (LC). However, in the pursuit of faster separations and increased analyte coverage, both gas- and condensed phase techniques such as ion mobility (IM), supercritical fluid chromatography (SFC) and size exclusion chromatography (SEC) have been implemented. Their orthogonality was explored in the metabolome characterization of a wide variety of biological and synthetic samples.
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