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Title page for ETD etd-04122010-131814

Type of Document Dissertation
Author Fenn, Larissa Spell
URN etd-04122010-131814
Title Detection and characterization of glycans and glycoconjugates using ion mobility-mass spectrometry
Degree PhD
Department Chemistry
Advisory Committee
Advisor Name Title
Prof. John A. McLean Committee Chair
Prof. Brian O. Bachmann Committee Member
Prof. Daniel C. Liebler Committee Member
Prof. Richard N. Armstrong Committee Member
  • collision cross section
  • ion mobility
  • mass spectrometry
  • glycoproteomics
  • glycomics
  • carbohydrate
Date of Defense 2010-04-09
Availability unrestricted
Many of the diseases associated with glycoprotein variation can be more effectively treated with earlier detection substantiating the need for high-throughput methodologies for glycoconjugate characterization. This remains particularly difficult due to heterogeneity, branching, and large size of carbohydrate moieties which makes them less amenable to conventional proteomic methods. The specific aim of this research is to develop intelligent strategies for the characterization of glycans and glycoconjugates using rapid (us to ms) structural separations by ion mobility and subsequent identification by mass spectrometry in pursuit of simultaneous glycomic, lipidomic, and proteomic characterization from complex biological samples.
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