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Title page for ETD etd-04122010-010048


Type of Document Dissertation
Author McDonald, Benjamin Seth
Author's Email Address ben.s.mcdonald@gmail.com
URN etd-04122010-010048
Title Development of the SiliSPECT Small-Animal Imager
Degree PhD
Department Physics
Advisory Committee
Advisor Name Title
Todd E. Peterson Committee Chair
John C. Gore Committee Member
M. Shane Hutson Committee Member
Thomas E. Yankeelov Committee Member
Will E. Johns Committee Member
Keywords
  • stacked detectors
  • synthetic collimator
  • silicon double-sided strip detectors
  • ASICS
  • Iodine-125
  • Small-Animal SPECT
Date of Defense 2010-03-24
Availability unrestricted
Abstract
SiliSPECT, a multi-pinhole, multi-detector SPECT system, was designed to image targeted regions of rodents at sub-300 micron resolution with stationary data acquisition. High spatial resolution is achieved with thick silicon double-sided strip detectors (DSSDs) and 250 micron pinhole apertures. Each of the two camera heads contain two stacked DSSDs, which collect four multi-pinhole projection images simultaneously, enhancing the total detection efficiency and permitting reconstruction based on the synthetic collimator method. The DSSDs were evaluated for imaging low-energy photons, such as the emissions from iodine-125. Trigger uniformity was improved with an iterative trim adjustment algorithm. Detection efficiency, dead time, charge-sharing, and other detector characteristics were measured. The system sensitivity, resolution, multiplexing and magnification of the full system were assessed. A calibration method was implemented to estimate the geometrical parameters of the system. SiliSPECT was fully characterized and readied for tomographic imaging studies.
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