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Title page for ETD etd-04112017-094307


Type of Document Dissertation
Author Hardeman, Keisha Nicole
URN etd-04112017-094307
Title Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
Degree PhD
Department Cancer Biology
Advisory Committee
Advisor Name Title
Ann Richmond Committee Chair
Christopher Chad Quarles Committee Member
Jamey Young Committee Member
Joshua Fessel Committee Member
Kimberly Dahlman Committee Member
Vito Quaranta Committee Member
Keywords
  • metabolic reprogramming
  • melanoma
  • cellular metabolism
  • glycolysis
Date of Defense 2017-03-23
Availability unrestricted
Abstract
Melanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were used to connect cellular metabolism to therapeutic proliferative response. The data show that forcing a glycolytic metabolic strategy in the context of drug treatment enhances the antitumor effect. Anti-retrovirals, particularly zalcitabine, were shown to dramatically affect proliferation when combined with BRAF inhibitor. All in all, this dissertation provides an important contribution to response variability and assay development, the glycolytic biology in relation to BRAF inhibition, and a finer inspection of variability within a tumor.
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