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Title page for ETD etd-04022007-233352

Type of Document Master's Thesis
Author Hariri, Ghazal
URN etd-04022007-233352
Title Radiation-Guided P-selectin Targeted Tumor Imaging in a Lung Tumor Model
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Dennis E. Hallahan Committee Chair
Todd D. Giorgio Committee Member
  • radiation therapy
  • P-selectin
  • tumor imaging
  • Drug targeting
Date of Defense 2007-04-02
Availability unrestricted
The objective of this study was to image tumor-targeting using a single chain fragment variable antibody to radiation-induced P-selectin in a heterotopic Lewis lung carcinoma model by near-infrared fluorescence imaging and gamma camera imaging. In our in vitro studies, we observed antibody binding to P-selectin in endothelial cells treated with radiation. In our in vivo optical imaging study, it was observed that significant tumor-specific binding was observed in irradiated tumors expressing P-selectin as compared to unirradiated tumors. Gamma camera imaging also showed successful targeting to P-selectin in irradiated tumors with tumor binding lasting for up to 10 days post-injection. Therefore, radiation-induced P-selectin is a feasible target for the tumor-specific delivery of therapeutic drugs and radionuclides in vivo.
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