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Title page for ETD etd-03312014-183105


Type of Document Dissertation
Author Zachman, Angela Laurie
URN etd-03312014-183105
Title Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease
Degree PhD
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Hak-Joon Sung, Ph.D. Committee Chair
Craig L. Duvall, Ph.D. Committee Member
Melissa C. Skala, Ph.D. Committee Member
Pampee P. Young, M.D., Ph.D. Committee Member
Scott A. Guelcher, Ph.D. Committee Member
Keywords
  • inflammation
  • injectable polymer
  • atherosclerosis
  • peripheral artery disease
  • peptide
  • angiogenesis
Date of Defense 2014-05-24
Availability unrestricted
Abstract
Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to promote collateral blood vessel formation, with a low degree of inflammation to minimize plaque development. However, these two processes are intrinsically linked and difficult to uncouple. Therefore, the overarching goal of this research was to develop a biomaterial system that enables controlled, dual delivery of pro-angiogenic and anti-inflammatory peptides in minimally-invasive way. To achieve the goal, a peptide-loaded injectable scaffold system was developed and tested in a mouse model of PAD. In addition, the mechanism of peptide-mediated regulation of angiogenesis and inflammation was elucidated. By regulating pathways involved in inflammation and angiogenesis independently, this dual peptide-loaded injectable scaffold system may significantly improve recovery of ischemic tissues in patients with PAD.
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